What dosage form does the injection belong to?
In the field of medicine, dosage forms refer to the different forms of drugs formed after processing to adapt to different administration routes and treatment needs. As a common dosage form, injection is widely used in clinical treatment. This article will introduce in detail the classification and characteristics of injection dosage forms, as well as the hot topics and hot content on the Internet in the past 10 days.
1. Classification of dosage forms of injections
Injections refer to dosage forms in which drugs are dissolved or suspended in a suitable solvent and directly injected into human tissues. Based on their physical state and use, injections can be divided into the following categories:
| Dosage form name | Features | Applicable scenarios |
|---|---|---|
| solution injection | The drug is completely dissolved in the solvent and is clear and transparent | intravenous injection, intramuscular injection |
| Suspension injection | The drug is dispersed in the solvent in the form of fine particles and needs to be shaken before use. | intramuscular injection, subcutaneous injection |
| Emulsion injection | The drug is dispersed in an aqueous phase in the form of an oil phase or liposomes | Intravenous nutrition, targeted drug delivery |
| Lyophilized powder for injection | The drug is stored in the form of freeze-dried powder and needs to be dissolved before use. | Drugs with poor stability |
2. Characteristics of injections
As a dosage form that directly enters the human body, injection has the following salient features:
1.Quick onset of effect: The drug directly enters the blood circulation or tissue, avoiding the first-pass effect of oral drugs.
2.High bioavailability: The drug does not need to be absorbed through the gastrointestinal tract, and the utilization rate is close to 100%.
3.Accurate dosage: Accurate drug delivery can be achieved by precisely controlling the injection volume.
4.Wide range of indications: Suitable for emergency, severe and patients who cannot take oral medication.
3. Hot topics and content on the Internet in the past 10 days
The following are hot topics and hot content related to injections in the past 10 days:
| topic | heat index | Main content |
|---|---|---|
| COVID-19 vaccine booster shot | ★★★★★ | Many countries have launched booster shots of the new coronavirus vaccine and discussed the protective effects and side effects |
| Insulin price regulation | ★★★★ | The U.S. government introduced an insulin price cap policy, attracting global attention |
| New anti-cancer injection | ★★★ | New progress in clinical research on targeted anti-cancer drugs such as PD-1 inhibitors |
| Safety of traditional Chinese medicine injection | ★★★ | Controversy and regulatory discussion on adverse reactions of traditional Chinese medicine injections |
| Intelligent injection system | ★★ | Wearable auto-injector technology breakthrough |
4. Precautions for clinical application of injections
Here are some important things to note when using injections:
1.Aseptic operation: Sterile operating procedures must be strictly followed to prevent infection.
2.Incompatibility: Pay attention to the incompatibility between different drugs to avoid adverse reactions.
3.Dosing speed: Certain drugs require strict control of infusion speed, such as potassium preparations, etc.
4.allergic reaction: Before use, understand the patient’s allergic history and prepare first aid measures.
5. Quality Standards for Injections
As a dosage form that directly enters the blood circulation, the quality standards for injections are particularly strict:
| Test items | Standard requirements |
|---|---|
| Sterility test | No microorganisms may be detected |
| bacterial endotoxin | Must not exceed specified limits |
| Visible foreign body | No obviously visible foreign matter shall be detected |
| pH value | Comply with the prescribed scope |
| Content determination | 90.0%-110.0% of the labeled amount |
6. Development Trend of Injections
With the development of medical technology, injection dosage forms are developing in the following directions:
1.Sustained and controlled release technology: Develop long-acting injections to reduce the frequency of administration.
2.Targeted drug delivery system: New drug delivery systems such as liposomes and microspheres.
3.Prefilled syringe: Improve medication convenience and safety.
4.biotechnology drugs: Development of injections of macromolecule drugs such as monoclonal antibodies.
Summary: As an important pharmaceutical dosage form, injection plays an irreplaceable role in medical practice. Understanding its dosage form characteristics, quality standards and development trends will help us use this type of medicine more safely and effectively. At the same time, paying attention to hot topics in the industry can also help us grasp the latest developments in the pharmaceutical field.
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